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Observation of Polymorphic Transition of Efavirenz during Heating by Raman Spectroscopy

Journal: International Journal of Science and Research (IJSR) (Vol.7, No. 7)

Publication Date:

Authors : ; ; ;

Page : 724-727

Keywords : Efavirenz; Polymorphic transition; Polymorph;

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Efavirenz as an anti-HIV type 1 drug has a lot of polymorph forms. The references reported it had 23 different polymorph forms include amorphous. But the only form I used in pharmaceutical market widespread which known as a stable form with poor solubility properties. Common knowledge that besides a stable form there is a meta-stable form which has more benefit in solubility. One of the meta-stable forms aim to study in this research was the form which result from methanol recrystallization. Characterization of form was slightly different both in diffractogram patterns from XRPD (X-ray Powdered Diffractometry) and the thermogram from DSC (Differential Scanning Calorimetry) comparing with a patent. Others characterizations were carried out such as Infrared (IR) vibration spectrums with IR absorption (Fourier Transform IR) and IR scattering (Raman Spectroscopy) to described polymorph functional groups response. To re-examined the polymorphic transition information from DSC the in-situ temperature dependent of Raman spectroscopy was conducted. There has only a little temperature shifting, from the thermogram the polymorphic transition of form taken place in the range 108.4110.4oC, but from Raman spectral information happen in 100115oC.

Last modified: 2021-06-28 19:21:40