Correlation of Subclinical Hypothyroidism and its Relation with Various Inflammatory Markers

Correlation of Subclinical Hypothyroidism And Its Relation With Various Inflammatory Markers SUBHASHINI SRINIVAS, TEENA EUGENE, KARKUZHALI, KHOWSALYA SUBRAJAA 1. ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY SREE BALAJI MEDICAL COLLEGE 2. SENIOR RESIDENT DEPARTMENT OF PATHOLOGY SREE BALAJI MEDICAL COLLEGE 3. PROFESSOR AND HEAD OF THE DEPARTMENT OF PATHOLOGY SREE BALAJI MEDICAL COLLEGE 4. BLOOD BANK OFFICER KAMAKSHI MEMORIAL HOSPITAL, CHENNAI Introduction Subclinical hypothyroidism shows the mimic reaction more like to frank hypothyroidism which creates the dilemma. Inflammatory markers can be helpful in assessment of adverse effects of subclinical hypothyroidism, are not very well studied in the past. So the aim of this study was to investigate the role of inflammatory markers in Subclinical hypothyroidism patients. Materials and Methods The study population consisted of 154 patients with recently diagnosed subclinical hypothyroidism and 100 healthy controls. TSH, FT4& T3 were estimated by enzyme linked Immunosorbent assay (ELISA) for diagnosis of subclinical hypothyroidism. Total cholesterol, triglycerides, and HDL-C were estimated by spectrophotometric method. LDL C was calculated by Friedewald formula. Inflammatory markers (ESR, C-reactive protein& Interleukin 6) were also estimated by enzyme linked Immunosorbent assay (ELISA). Results In this study the level of TSH Mean SD (11.124.17 vs 2.730.80) and T3 Mean SD (0.960.17 vs 1.080.26) were significantly higher (