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Copper (I)-N, N-Dimethyldipropylenetriamine Catalyzed Robust Homocoupling of Terminal Alkynes

Journal: International Journal of Science and Research (IJSR) (Vol.7, No. 10)

Publication Date:

Authors : ; ;

Page : 1506-1510

Keywords : homocoupling; copper catalysis; acetonitrile; terminal alkynes; 1; 3-diyne; DMAPAPA;

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A robust catalytic system consisting of Cu (I) -salt and dimethyldipropylenetriamine for the synthesis of 1-4-disubstituted 1, 3-diynes have been developed. The new protocol involves homocoupling of terminal alkynes in the presence of CuI or CuCl and DMAPAPA as ligand in acetonitrile. A seires of terminal alkynes having diverse functional groups are converted to corresponding 1, 3-diynes via homocoupling under ambient conditions within an hour in excellent yields upto 98 %. The current protocol avoids stoichiometric amount of copper salt and high cost palladium salt, and harsher condition.

Last modified: 2021-06-28 20:15:55