The State of the System of Matrix Metalloproteinases and of their Tissue Inhibitors in Patients with Metabolic Syndrome

Metabolic syndrome (MS) is a disease with a complex aetiology. Its main signs include hypertension, insulin resistance, obesity and dyslipidaemia. Since MS is associated with the involvement of heart and blood vessels, the researchers pay great attention to the role of extracellular matrix (EM) in the processes of geometric remodelling of myocardium in patients with cardiovascular system disorders. Thus, we have defined a significant role of MMP-1 and TIMP-1 system in the EM remodelling in patients with MS. In patients with MS and AH associated with metabolic disorders, such as IR and OB, decreased plasma MMP-1 and increased TIMP-1 are accompanied by myocardial extracellular matrix remodelling with subsequent formation of left ventricular geometry of a certain type.