Boric Acid Inhibits Cell Growth in SH-SY5Y Neuroblastoma Cell Lines

Boric acid (BA) form of boron is the most common in humans. BA is a weakly unionized acid at the physiological pH. In the current study, we investigated to cytotoxic effect of BA on SH-SY5Y cell line. Boric acid used in this study is commercially purchased. The boric acid was dissolved in water by probe sonicator under certain conditions and characterization analyses were carried out. The synthesized BA was applied to the neuroblastoma SH-SY5Y cell line and the cytotoxic effect of BA were determined by using MTT method. SH-SY5Y cells were treated with different concentrations of BA (1-200g/ml) for 24, 48 and 72 hours. The effects of boric acid-water on the neuroblastoma SH-SY5Y cell line were compared to the control group and IC50 values were found for 24, 48 and 72 hours. In this study, it was shown that the effect of boric acid-water system on neuroblastoma SH-SY5Y cell was inhibitory to growth in cancer cells compared with control group. However, there is no study on boric acid-water so far. This study will provide new information in that regard.