Antimutagenic / Antigenotoxic Activity of Bioactive Compounds of Curcuma caesia rox b against Cyclophosphamide induced Hepatotoxicity and Nephrotoxicity in Mice

The present study has focused on the antimutagenic effects of bioactive compounds of Curcuma caesia rox b (Black turmeric) against mutagenic effects of cyclophosphamide induced hepatotoxicity and nephrotoxicity in mice. Bioactive compounds in plants can be defined as secondary plant metabolites eliciting pharmacological or toxicological effects in man and animals. These are produced within the plants associated with plant growth and development and are regarded as products of biochemical side tracks in the plant cells which also play an important role in curing various kinds of diseases like cancer, diabetes etc. Method: The present study evaluated the bioactivity of proteins in aqueous extracts of rhizomes of the species. This species are used in traditional Indian medicine for their antimicrobial, anticancer, anti-inflammatory properties. Total phenol content was estimated by the Folin-Ciocalteau method. The highest total phenol content was exhibited by aquoeous extracts. This species showed a significant antioxidant activity in aquoeous extract.