Study of Prevalence and Antimicrobial Susceptibility Pattern of Uro-Pathogenic Escherichia Coli among Patients in Private Hospital Chennai

Background& objectives: Escherichia coli causing urinary tract infection (UTI) especially among patients and antibiotic resistance pattern is increasing. so we undertook this study to know the antibiotic resistance pattern of E. coli causing UTI in patients hospital in south India, and to know its antibiotic sensitivity pattern. Methods: 210 samples of urine of ICU patients which had significant bacterial grown in culture and antibiotic sensitivity pattern was taken from microbiology lab samples were processed using standard methods and by using Kirby-Bauer disk diffusion test, antibiotic susceptibility was checked. Results: 500 cases were taken from ICU patients for urine culture, 110 case had E. coli in culture, 81 (73.6 %) were multi drug resistant (MDR). The isolates showed high levels of resistance to Ampicillin (76 %), cefotaxime (61.5 %), ceftriaxone (61.5 %), norfloxacin (53.8 %), and co-trimoxazole (46.2 %). The isolates were sensitive to meropenem (83 %), amikacin (81 %), levofloxacin (81 %), piperacillin-tazobactum (83 %), nitrofurantoin (72 %) and imipenem (84 %). Ceftriaxone was most commonly used for empirical therapy for UTI among in patients in our hospital. Interpretation& conclusions: This study showed that 73.6 percent of E. coli, isolated from urine samples of patients were MDR. The use of empirical therapy with cephalosporins in patients has led to increased antibiotic resistance.