An In Silico Approach: Homology Modelling and Docking Studies of Rabies Virus Glycoprotein with Salviifoside A of Alangium salviifolium

The genome of rabies virus encodes five proteins, the nucleoprotein, the phosphoprotein, the matrix protein, the glycoprotein, and the RNA-dependent RNA polymerase. Among these, the glycoprotein is the most important as it is the major contributor to pathogenicity and virus neutralizing antibody response. Keeping in mind that glycoprotein is the only protein exposed on the surface of virus and is thought to be responsible for the interaction with the cell membrane, it was attempted to target glycoprotein by a ligand salviifoside A of Alangium salviifolium which blocks its active site, so that it may be possible to prevent the spread of virus into the host. The ligand salviifoside A of Alangium salviifolium was retrieved from Pubchem and docked with modelled Rabies Virus Glycoprotein (RVG). This knowledge may be important for the further research studies and aid in treatment of rabies and other viral diseases in the future.