A Study of Prolactin as a Diabetogenic Factor in Type I&Type II Diabetic Patients

Aims& Objectives 1) To study the serum levels of prolactin in 30 normal healthy persons& 30 Type I& 30 Type II Diabetes Mellitus (DM) patients.2) To assess prolactin as a most suitable parameter for prognosis& treatment of DM patients. Materials& MethodsThe present study was carried out in Dept. of Biochemistry, GMC, Nagpur from May 2003 to May 2005. A total of 60 patients diagnosed as having DM aged between 15 80 years were selected from the diabetic OPD of GMC, Nagpurunder Dept. of Medicine& 30 normal healthy volunteers aged 15 80 years were selected as control after satisfying all inclusion& exclusion criteria& willing to give consent. The subjects were divided into three Groups as Group I (30, control), Group II (30, Type I DM paatients)& Group III (30, Type II DM patients). Serum PRL levels was estimated using ELISA LISA kit supplied by transasia, Mumbai. ResultsThe results presented in the table indicates that PRL levels in Type I& Type II DM in males& females are not siginificantly changed as compared to controls. Discussion Lowering PRL failed to improve GTT or alter insulin release. It was concluded that PRL has no significant effect on glucose disposal.