Synthesis and Characterization of Some New Schiff Bases Derived from 7-hydroxy-4-methyl Coumarin

Coumarins induce researchers for further developments in organic synthesis because of their pharmaceutical and biological activities. The current research aimed to synthesize new Schiff bases derived from 7-hydroxy-4-methyl-coumarin containing amide, hydrazine carbothioamide, ethylidene moieties. Compound (1) (7-hydroxy-4-methyl coumarin) was converted into quinolin-2 (H) -one derivative (2) by the reaction with acetamide. Reaction of derivative (2) with thiosemicarbazide in ethanol leads to the synthesize of (7-hydroxy-4-methyl-2-oxoquinolin-1 (2H) -yl) ethylidene) hydrazinecarbothioamide derivative (3). Schiff bases (4-6) are prepared through the reaction of (3) with one of aldehydes or ketone. New coumarin derivatives are characterized by their physical properties and various spectral analysis like FTIR, 1HNMR, GC-Ms spectra and micro elemental analysis (C. H. N. S) technique for some of them.