Effect of Polyalthia Longifolia Leaves on Liver Carcinogenesis

This experiment with four groups of rats was designed to evaluate the beneficial properties of polyalthia longifolia consumption on antioxidant enzyme regulation and lipidperoxidation in albino rats in DEN induced stage. For the study, the male albino rats were divided into four groups normal, chemical treated and chemical along with the methanol extract of plants treated groups for initiation phase. The Intraperitonial injection of DEN with one day and 15 days incubation caused carcinogenesis and the other group had plant treatment up to 15 days. Effects of polyalthia consumption on LPO and antioxidants enzymes changes were also evaluated. The plant treatment had remarkable effects on LPO and antioxidant enzymes level changes in the male albino rats. An improvement in lipidperoxidation and antioxidants enzymes were observed with lower lipidperoxidation and improved antioxidant enzymes changes after 15 days of polyalthia longifolia methanol extract treatment. Thus the leaf polyalthia longifolia was found to have antioxidant /antidegradative activity.