Evaluation of Thyroid Function in Patients of Chronic Renal Failure in Khartoum State ? Sudan

3 Dean of Faculty of Medical Laboratory Sciences- University of Alzaeem Alazhary- Sudan. Background The functions of thyroid and kidney are interrelated, Various Studies of thyroid functions in uremic patients have been carried out which have shown conflicting results. Methodology A matched case-control study was conducted in 50 patients with CRF and 50 healthy subjects, Patients were studied more than once (before and after Hemodialysis' HD') for Serum Triiodothyronine (T3), Serum thyroxin (T4) and Serum thyroid stimulating hormone (TSH). Parameters were measured by Enzyme Linked Immunosorbent Assay (ELISA). Results the mean of T3 levels in cases was 75.4025.05 ng/dl and in controls was 132.7230.58 ng/dl. The mean of T4 level in cases was 5.771.40g/dl and in controls was 7.961.71g/dl. The mean of TSH level in cases was 4.78 2.24IU /ml and in controls was 2.11.29 IU /ml. The mean of T3 pre hemodialysis was 75.4025.05 ng/dl and post hemodialysis was 81.822.42 ng/dl. The mean of T4 pre hemodialysis was 5.771.404 g/dl and post hemodialysis was 6.171.446 g /dl. The mean of TSH pre hemodialysis was 4.782.246 IU/ml and post hemodialysis was 4.261.989 IU/ml. Conclusion The Means of T3, T4 were decreased, and that of TSH was increased significantly in cases compare to controls. The patients after HD show increment of T3 and T4 and reduced TSH if measured immediately after HD sessions. Chronic renal failure (CRF), Hypothyroidism, Hemodialysis (HD).