Circulating 25-Hydroxyvitamin D and Insulin Resistance in Patients with Coronary Heart Disease

Background Coronary heart disease (CHD) is a global epidemic, insulin resistance (IR) one of the predictors of coronary heart disease. Low concentration of vitamin 25-Hydroxyvitamin D ( 25 (OH) D) associated with IR. The aim of our study was to explore the associations between 25 (OH) D and indexes of IR among patients with CHD. Methods This casecontrol study included 100 unrelated subjects.60 patients with CHD and 40 healthy control group. Serum 25 (OH) D levels were measured using a high-performance liquid chromatography (HPLC) according to. Results Our results revealed that diabetic patient with CHD had significantly lower values of serum 25 (OH) D compared to non-diabetic group as well as control group, there were significant negative correlations between serum 25 (OH) D levels and HOMA-IR as well as other studied parameters. Receiver operating characteristic analyses (ROC) revealed that the cut-off value of serum 25 (OH) D levels was 31.1and the AUC was 0.996. The sensitivities and the specificities were 98.3 %and 75 %. Conclusion 25 (OH) D levels are significant low in CHD patients as well as diabetic subgroup compared to non-diabetic group.25 (OH) D levels are strongly correlated with insulin resistance thus low25 (OH) D could be used as marker of insulin resistance.