Prevalence of Antifungal Resistant Strains of Candida Species in Immunocompromised Patients

The invitro susceptibilities of 50 Candida species isolates were tested against two antifungal agents by a disc diffusion of CLSI M44-A2 method for fungal susceptibility testing. The Candida species shows resistance towards Amphotericin B and fluconazole. According to the results obtained, candida albicans was the, most frequently isolated with 86 %, this was followed by C. tropicalis 4 %, C. krusie 2 % and C. parapsilosis 2 %. In the current study it is found that a number of Candida isolates resistant to amphotericine B were 46.5 % where as 11.9 % strains were interpreted as semi dose dependent and non-albicans Candida all showed 100 % resistance to Amphotericine B. However, the study with fluconazole shows 65 % of Candida isolates were resistant whereas, non-albicans candida all showed 100 % resistance.