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RP-HPLC Method Development and Validation for the Analyisis of Pharmaceutical Drug ? ACECLOFENAC

Journal: International Journal of Science and Research (IJSR) (Vol.6, No. 7)

Publication Date:

Authors : ; ;

Page : 1318-1320

Keywords : Aceclofenac; Method Development; Validation; 210nm; 30min;

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A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of ACECLOFENAC. Isocratic elution at a flow rate of 1.2 ml /min was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Acetonitrile 0.1M Acetic Acid 6040 (v/v). The UV detection wavelength was at 210 nm. Linearity was observed in concentration range of 0.01-0.05 gm/ml. The retention time for ACECLOFENAC was 3.0 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of ACECLOENAC.

Last modified: 2021-06-30 19:29:57