New Mode for Long Path Irradiation and Two Sided Detection for the Determination of Ibuprofen in Pure and Pharmaceutical Drugs using Continuous Flow Feed via the use of ISNAG Fluorometer InstrumentJournal: International Journal of Science and Research (IJSR) (Vol.6, No. 8)
Publication Date: 2017-08-05
Authors : Proph. Nagam Shakir Turkie; Hussein Fares Abd-Alrazack;
Page : 201-216
Keywords : Ibuprofen; flow injection diverged light; homemade instrument;
A new, simple, accurate, fast and sensitive method has been developed for the determination of Ibuprofen in pure form and drugs (tablets) by continuous flow injection diverged light. The method was based on the reaction of the Ibuprofen with potassium chromate to formed a precipitate, using homemade ASNAG- fluorimeter. Optimum parameter have been studied to increase the sensitivity for developed method. The linear dynamic range for the instrument response versus Ibuprofen concentration was 5- 30mmol/L while the L. O. D was 1.630g/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The correlation coefficient (r) was 0.9886 while percentage linearity (R2 %) was 97.74 %. RSD % for the repeatability (n=8) was lower than 0.5 % for the determination of Ibuprofen, with concentration of 5, 30 mmol/L respectively. The methods developed method was applied successfully for the determination of Ibuprofen in pharmaceutical tablets. A comparison was made between the newly developed method with the classical method (UV-Vis spectrophotometry at wavelength 220nm, and Turbidemtric method) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted value of each individual company with calculated t-value at 95 % confidence interval from developed method.
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