The Profile of Angiotensinogenpolymorphism (AGT RS 699) and Working Memory on Hypertension Patients

Introduction. One of the most common cognitive disorders in hypertensive patients is working memory. Gene polymorphisms associated with hypertension are the Renin Angiotensin System. Angiotensinogen gene known as RAS encoding associated with hypertension is RS 699. Currently, there is not much known about the difference of working memory in hypertensive patients with variant of AGT RS 699 gene compared with work memory score and polymorphism. Objective. To know the difference of working memory score in hypertension patient with AGT RS 699 gene variant by comparing the working memory score of AGT RS 699 gene polymorphism. Method. The sample of 34 people with hypertension in Hasan Sadikin Hypertension Hospital Polyclinic in Bandung was taken using the sampling technique of sampling. The results were analyzed by comparing the working memory score of AGT RS 699 gene polymorphism through Mini Mental State Examination (MMSE) examination, task list word, recall word list, digit span and omission vigilance. Results. The prevalence of AGT RS 699 polymorphism in hypertension patients was 23.53 %. Samples that do not have AGT RS 699 gene polymorphism have result of working memory examination with higher mean value than polymorphism sample. A significant association between AGT RS 699 gene polymorphisms was demonstrated only by checking of the task list (p less than0.05). Hypertensive patients with AGT RS 699 polymorphism have a tendency to have a value of the word list task 2.6 times lower than that of non-polymorphism. Conclusion. The risk of working memory on polymorphism of AGT RS 699 gene lower than AGT RS 699 gene which is not polymorphism.