Synthesis of a Novel Series of Dioxazolines by 1.3-Dipolar Cycloaddition between N-alkyl 5-Chloroisatin Derivatives and Nitrile Oxides

A new series of dioxazoline of 5-Chloroisatin derivatives has been designed and synthesized involving 1, 3-dipolar cycloaddition reaction, preceded by a simple N-alkylation reaction in phase-transfer catalytic conditions The regioselectivity of the reactions was ascertained by 1H, 13C NMR spectroscopy of the synthesized compounds.