Rare Case of Multiple Endocrine Neoplasia Type 1 in Algeria: Breast Cancer (hyperprolactinemia), Cushing's Syndrome and Empty Sella Syndrome

Multiple endocrine neoplasia type 1 (MEN1) syndrome is a hereditary disorder, sometimes it is sporadic. The prevalence of MEN1 in the general population is estimated to be between 1/20 000 and 1/60 000 inhabitants [1]. In our study, we found 22 cases of MEN1 from the north, south and east hospitals of Algeria, in 5 years of research. This is too lower than other countries prevalence. Two-thirds of all cases are female patients. We found a rare case, female has hyperparathyroidism and breast cancer (hyperprolactinemia) associated with an empty Sella and Cushings syndromes. After biological analyzes, normal levels of ACTH and cortisol were found, and a high level of PTH. After an exhaustive personal and family history and clinical assessments, we considered as a case of MEN1 disease that triggered by a pituitary tumor with or without hypothalamic tumor, followed by breast cancer and hyperparathyroidism.