Micro Pericytes Coverage in Relation to Different Grades of Oral Squamous Cell Carcinoma

Background Angiogenesis is an important step in Oral Squamous Cell Carcinoma (OSCC) growth, progression, and metastasis. Micro Vessel Density (MVD) can reflect the angiogenic rate but not gives knowledge about the efficiency state of newly formed vessels. Measuring of micro vessel pericytes coverage index (MPI) for these blood vessels can determine the degree of their maturation. Aim of the study this study established to determine the association of between MVD, MPI and clinicopathological parameter of OSCC. Material and Methods Retrospective 36 formalin- fixed, paraffin-embedded tissue blocks histologically diagnosed as OSCC were examined for MVD and MPI were assessed by conventional immunohistochemistry staining using anti-CD105 and anti -SMA antibodies respectively. Results Highly significant association of MPI and histological grade of OSCC (P=0.000), while no significant difference between MVD and clinicopathological parameter of OSCC. Conclusion Both of MVD (using CD105) and MPI can considered as signs of the angiogenic and functional status of a tumor vascularity.