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Synthesis, Characterization and Antimicrobial Activities of Some Pyrazoline Derivatives

Journal: International Journal of Science and Research (IJSR) (Vol.3, No. 9)

Publication Date:

Authors : ; ;

Page : 1217-1219

Keywords : Microwave irradiation; Pyrazolines; spectral data; antibacterial activity;

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Abstract

Some new fused pyrazolines3-methyl-1, 4, 5-triphenyl-1, 3a, 4, 5tetrahydropyrazolo [3-4c]pyrazole, 4 (4-Bromophenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole, 4 (4-chlorophenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole 4 (4-Nitrophenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole, 4 (4-methoxyphenyl) 3 methyl -1, 5-diphenyl -1, 3a, 4, 5 tetra hydrophyrozolo [3, 4c] pyrazole, 4 (4 methyl -2, 6-diphenyl -2, 3, 3a, 6 tetra hydrophyrozolo [3, 4c] pyrazol-3-yl) phenol, pyrazole are prepared by condensation of 1-phenyl-3-methyl-5-pyrazolone with substituted benzaldehyde under microwave irradiation afford chalcones which under cyclization with phenyl hydrazine to afford fused pyrazolines. Synthesized compound confirmed by suitable spectroscopic technique such as 1HNMR. The compounds were screened for their in antibacterial activity against S. aureus E. coli, S. typhi bacteria.

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Last modified: 2021-06-30 21:07:44