Study of Prognostic Value of Rheumatoid Factor and Anti Cyclic Citrullinated Peptide Antibodies in Patients with Rheumatoid Arthritis

Aims and Objectives: To correlate Rheumatoid factor (RF) and Anti-CCP antibody in RA - To evaluate prognostic value of RF and Anti-CCP antibody in RA. Methods: Retrospective study of total 40 patients admitted to our hospital between april 2013 to may 2014. All patients were diagnosed as rheumatoid arthritis as per diagnostic criteria of American College of Rheumatology. All patients had symptom duration of at least year. Anti-CCP and IgM-RF were evaluated in all patients. Disease activity score 28 was calculated in all patients. Radiological Damage was assessed by Larsen Score. Results: Anti-CCP and RF were significantly correlated with each other and both were seen as significant independent predictors of radiological outcomes. Combination of these two had the highest risk for erosive joint damage. Conclusion: RF and Anti-CCP antibodies are significantly correlated with each other and both are having a high predictive value for erosive joint disease. Combined use of RF and Anti-CCP has high predictive value for erosive joint disease than RF or Anti-CCP alone and may facilitate to make a decision about the individual treatment in Rheumatoid arthritis.