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ESTIMATION OF MONTELUKAST SODIUM AND FEXOFENADINE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY Q-ABSORBANCE METHOD

Journal: International journal of Pharmaceuticals and Health care research (Vol.01, No. 1)

Publication Date:

Authors : ;

Page : 09-14

Keywords : Fexofenadine hydrochloride; Montelukast sodium; Q-absorbance method.;

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Abstract

A simple precise, accurate, cost effective method has been developed for the estimation of Montelukast sodium and Fexofenadine hydrochloride in combined tablet dosage form by Q-absorbance method. The isobestic point was found at 226 nm. The developed method showed linearity in the range of 5-25 ?g/ml for both drugs. LOD and LOQ values were found to be 2.3 ?g/ml and 3.45 ?g/ml for Montelukast sodium and 2.67 ?g/ml and 3.35 ?g/ml for Fexofenadine hydrochloride respectively. The % RSD values were within the acceptable range. The developed method has been validated as per ICH guidelines.

Last modified: 2013-04-30 21:56:35