Malignant Peripheral Nerve Sheath Tumour (MPNST) of Common Peroneal Nerve - Case Report

Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas which originate from peripheral nerves or from cells associated with the nerve sheath, such as Schwann cells, perineural cells or fibroblasts. World Health organization (WHO) coined the term MPNST replacing previous heterogeneous and often confusing terminology such as malignant schwannoma, malignant neurilemmoma and neurofibrosarcoma, for tumors of neurogenic origin and similar biological behavior. A combination of gross, histopathological and immunohistochemical studies are used for diagnosing these tumors. We herein present a case of MPNST arising from common peroneal nerve with neuro-vascular encasement and extensive soft tissue without bone involvement.