A Study on Use of Tranexamic Acid in Reducing Blood Loss during Lower Segment Caesarean Section

Aim of the study To study the effectiveness of anti fibrinolytic agent Tranexamic acid in reducing blood loss during and after lower segment caesarean section. Materials& Methods This was a randomized, case controlled, prospective study on 100 women undergoing LSCS (between February 2013 and January 2014).50 patients were given tranexamic acid 1gm slow IV 20 minutes before LSCS& were compared with 50 others who did not receive tranexamic acid. Blood lost was collected and measured during the two periods the first period was from placental delivery to the end of LSCS and the second from the end of LSCS to 2 hours post partum. Results Tranexamic acid significantly reduced the quantity of blood loss during LSCS (298.4+_72.4 ml) in the study group versus (329+_56.9 ml) in the control group. It also significantly reduced the quantity of blood loss from placental delivery to 2 hours post partum (360.7 +_ 110.9 ml) in the study group, versus 443+_ 88.65 ml in the control group. (P= 0.0008). No complications or significant side effects were reported in either group. Conclusion Tranexamic acid significantly reduces the blood loss during and after the caesarean section. Side effects eg. nausea, vomiting, diarrhea& thrombosis are rare. Thus, Tranexamic acid can be used effectively in women undergoing LSCS to decrease the blood loss.