Study of Plasma Homocysteine Level in Coronary Heart Disease Patients and Compare with Control

The study was conducted on 50 patients of coronary heart disease and 50 persons are healthy subjects between the age group 25-70 years of both sex. Homocysteine may increase cellular oxidative stress in which mitochondrial thioredoxin, and peroxidation are decreased and NADH oxidase activity is increased and generating peroxinitrite and nitrotyrosine in contractile protein which causes vascular dysfunction. Plasma homocysteine were measured by hplc grade kit with the help of HPLC. plasma homocysteine level of coronary heart disease patients showed a highly significant (p0.0001) relationship. Estimation of plasma homocysteine is reliable, economic and sensitive and it can be used in the proper management of chronic complications of coronary heart disease.