Experimental Correlation between Different Routes of Commercial Hair Dye Administration and Renal Toxicity

Objective To examine the effect of hair dye toxicity on the renal function among experimental rats by using different Administration routes. Methods A randomized controlled trail was conducted. Albino Wistar Rats were obtained from the Faculty of Pharmacy, University of KhartoumSudan. The rats were divided into two batches based on oral or subcutaneous administration, each batch had four groups (control and three test groups) each comprising six rats. Batch-1 and batch-2 (group-2, 3, and 4 with 10, 20, and 30mg/kg body weight (BW) where orally and subcutaneously administered respectively. The study was conducted in the period from July 2013 to February 2014. Results The clinical features were shown in all rats batches ranged from slight weakness in group 2 to pharyngeal oedema in group-3 up to severe weakness in hinds and fore limbs with severe convulsions, and respiratory difficulty prior to death in group-4. The Biochemical parameters showed significant increase in serum creatinine and urea concomitant with the increase of the commercial hair dye dosage in the two batches (Pless than0.05 and Pless than 0.005 respectively), and significant decrease in serum albumin (Pless than0.05) and uric acid (Pless than0.005). Potassium was significantly high among treated rats (Pless than0.05). Oral administration showed more renal toxicity compared with the subcutaneous route.