Hematological and Clinical Changes in Rabbits Exposed to Lantana Camara under Experimental Conditions

Lantana camara is well known to cure several diseases and used in various folk me-dicinal preparations. The objective of this study was to investigate the chronic toxicity of Lantana camara, in rabbits exposed to fruit and leaf of the plant in powder form in feed from hematological and clinical points of views. Methods to evaluate the chronic toxicity, a fixed dose of 5 g / kg body weight of L. camara fruit and leaf in powder forms were giving with feed as pellet daily for 14 days. The main parameters depended in the experiment were, body weight, respiratory rates, heart rats and body temperature from clinical point of view. In addition to determination of bleeding and clotting times, with estimation of erythrocytes counts, Hemoglobin concentration, Packed cell volume, and erythrocytes indices ( MCV, MCH, MCHC), leucocytes counts, differential leucocytes count ( lymphocytes, Heterophils, Eosinophlils, Monocytes and Basophils %) Results in 28 days L. camara leaf and fruit powder showed no obvious chronic tox-icity. The rabbits exposed to lantana showed changes in clinical parameters, in addition to the hematological parameters. As they showed, loss body weight, decreased respiratory rates, heart rates. With decreased counts of erythrocytes, Hb concentration, PCV values, prolongation of bleeding and clotting times. While the total and differential count did not show significant changes.