Evaluation of Malondialdehyde and Nitric Oxide and its Impact on Sperm Quality Parameters in Oligospermic Infertile Men

Male reproductive function is found to be defective in 50 % of infertile couples. Oxidative stress induced lipid peroxidation is one of the potential cause of the male infertility. Present study was aimed to evaluate malondialdehyde and nitric oxide in oligospermic infertile and fertile men and to study correlation of malondialdehyde and nitric oxide with sperm parameters. The study is prospective, comprises 30 oligospermic infertile men and 30 fertile men. Seminal MDA and NO. levels were evaluated spectrophotometrically. The levels of MDA and NO. were found to be significantly increased in oligospermic infertile men as compared to fertile men. MDA and NO. levels were negatively correlated with sperm count and sperm motility. This suggests that oxidative stress induced lipid peroxidation can cause poor semen quality. Therefore assessment of MDA and nitric oxide will help to understand an etiology of infertile men and to decide treatment strategies.