Familial Aggregation of Type 2 Diabetes Mellitus in Rural India

Aim To evaluate familial transmission, age and sex distribution of type2 diabetes mellitus in rural population. Materials and methodsThis is a cross-sectional study which was conducted among diabetic patients visiting NRIGH from January 2015 to June 2015. The study included patients diagnosed as T2DM as per WHO criteria [4] and attending regularly to medical OPD, taking oral hypoglycemic drugs. In this study, multistage stratified cluster sampling was employed using the administrative divisions of Tenali mandal. Of the 300 patients approached from different settlement areas of the mandal, 267 agreed to participate and gave verbal consent to take part in this study. Results Patients above 30 yrs were taken in to study. Patients ranged from 30yrs to 85 yrs. Most patients were between age group 40 and 49 i. e.80. Average age of onset of diabetes is 47.8 yrs. There was no much difference in gender ratio MF = 133134 Out of 267 patients, family history of diabetes was evaluated and was present in 177 patients. The prevalence of DM in father, mother, brother and sister was 19.4 %, 23.2 %, 23 % and 20 % respectively. In 2nd degree relatives for uncles and aunts, a positive history of T2DM was more common among maternal aunts/uncles than in paternal aunts/uncles (31.0 % vs 22.0 %). Both maternal and paternal transmission of diabetes was present in 15 patients [5.6 %]. Conclusion In conclusion, the study findings showed an excess of maternal transmission of T2DM in rural India. The data support the dominant maternal role in the development of diabetes mellitus in their offspring.