Effect of Ethanolic Extract of Semecarpus Anacardium Fruit on Carrageenan Induced Paw Edema in Albino Rats

Background Semecarpus anacardium plant derivatives has been used since antiquity, The fruit and nut extract of Semecarpus anacardium shows various activities like antiatherogenic, anti-inflammatory, antioxidant, antimicrobial, antireproductive, CNS stimulant, hypoglycemic, anticarcinogenic. The present study is an attempt to explore the anti-inflammatory activity of ethanolic extract of fruits of Semecarpus. anacardium plant in albino rats by employing carrageenan induced rat hind paw edema model. Methods Acute anti-inflammatory model performed on wistar male albino rats (150-200gm) were divided into 4 groups, each group containing 6 albino rats, group 1 serving as control, group 2 as standard, group 3 receiving 300mg/kg. b. wt of ethanolic extract of Semecarpus anacardium fruit and group 4 receiving 600 mg/kg. b. wt of ethanolic extract of Semecarpus anacardium fruit. The anti-inflammatory property was assessed by Plethysmograph. Results Ethanolic extract of Semecarpus anacardium fruit demonstrated a significant anti-inflammatory property at different levels when compared to control and standard (pless than 0.05). Conclusion Ethanolic extract of Semecarpus anacardium fruit exhibited a dose dependent anti-inflammatory activity in carrageenan induced rat paw edema model of inflammation and shows that this is a potent source of phytomedicine development in the future.