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Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer
Journal: International Journal of Science and Research (IJSR) (Vol.4, No. 9)Publication Date: 2015-09-05
Authors : Enas Sami Ali; Ahlam J. Qasir;
Page : 992-995
Keywords : Nalidixic acid; Mafenide acetate; Pro drug; Antibacterial; glycine and phenylalanine;
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Abstract
The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual pro drugs were synthesized by coupling Mafenide acetate with Nalidixic acid by amino acid spacer (glycine or phenylalanine), and evaluated for in-vitro antibacterial activity with significant results.
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