Antibacterial and Antifungal Activities of Curcuminoid Analogue with Chloro Substituted Phenyl Ring and the Transition Metal Chelates

Natural plant products have been used throughout human history as they possess biological activity that can be exploited in pharmaceutical drug design. In recent years there has been an increased enthusiasm in treating the diseases by natural products. Curcumin, the bioactive pigment in Turmeric has a huge therapeutic value. Curcumin, its analogues and metal complexes have been extensively studied for their biological activities including antimicrobial, anti-inflammatory, antioxidant, anticarcinogenic etc. Recently a number of compounds structurally related to curcuminoids were synthesized and their biological activities have been studied. In the present study, the synthesis and characterization of a curcuminoid analogue with chloro substituted phenyl ring and its metal chelates Cu (II) & Oxovanadium (IV) are discussed here. The curcuminoid analogue 1, 7-bis (4-chloro phenyl) hepta-1, 6-diene-3, 5-dione and the metal chelates were synthesized and characterized using UV, IR, 1H NMR and mass spectral data. Antifungal study of the compounds were done using Kirby Bauer method and Antibacterial study was conducted by Agar well diffusion method. The present investigation reveals that the Cu (II) complex show enhanced antibacterial activity and Vanadyl complex exhibited better antifungal activity than the curcuminoid analogue.