The Protective Role of Ginger on the Testicular Tissue and Testosterone Hormone of Male Rats Exposed to Mono Sodium Glutamate

Background Monosodium glutamate (MSG) is commonly used food additive and flavor enhancer and it causes tissue damage through its oxidative stress effects. Objective This study has been carried out to evaluate the protective effects of aqueous extract of Ginger on the Monosodium glutamate induced histomorphometric testicular tissue and hormonal alteration in male rats. Material & Methods Twenty four adult male rats were divided into 3 equal groups the 1st group was designed as control, the 2nd administered MSG orally at dose 4g/kg body weight for 14 days and the 3rd group treated with MSG at dose of 4mg/kg body weight plus Ginger extract at dose 100mg /kg body weight for 14 days. Results showed that MSG has altered the microarchitecture of testicular tissues reduced seminiferous tubule diameter and spermatogenic epithelial thickness, increased the interstitial spaces with reduction in Leydig cells and Testosterone hormone level in addition Ginger extract has prevented the MSG effect all the results were significant statistically. It is concluded that Ginger has protective and improving role against the oxidative stress effects induced by MSG on the rat testicular tissue.