Outcome Analysis of Cardiac Resynchronisation of Moderate to Severe Heart Failure in Relation to Blood Pressure Exercise Tolerance and Electrocardiography Changes

In approximately 30 % of patients with chronic heart failure the disease process not only depresses cardiac contractility but also affects the conduction pathways, causing delay in the onset of right/left ventricular systole. This dyssynchrony is apparent on the electrocardiogram (ECG) as a widened QRS of more than 120 msec. The finding of an intraventricular conduction delay has been associated with clinical instability and an increased risk of death in patients with heart failure. In recent studies it has been found that use of atrial-synchronized biventricular pacing can improve cardiac function, enhance functional capacity and the overall quality of life. Even though this method has received FDA (Food and Drug Administration) approval in 2001 as standard treatment, no long term studies have been conducted to know the outcome in these patients. Keeping in view the above facts / findings there is a need to study the outcome of cardiac resynchronization in patients with moderate to severe heart failure.