Anticonvulsant Activity of the Decoction of Crossopteryx febrifuga in Mice

The decoction of Crossopteryx febrifuga is evaluated for anticonvulsant activity in mice using strychnine (STR), picrotoxin (PIC), pentylenetetrazole (PTZ), maximal electroshock (MES) and isonicotinic hydrazid (INH) induced convulsions. A decoction of C. febrifuga at doses of 80 and 100 mg/kg protects 83.33 % of mice against STR-induced convulsions. At the dose of 120 mg / kg, it protects 100 % of mice against PIC-induced convulsions. On PTZ-induced convulsions, C. febrifuga decoction protects 66.67 % and 100 % of mice, respectively at doses of 120 and 100 mg / kg. While 66.67 % and 83.33 % of mice are protected against MES-induced convulsions respectively at the doses of 100 and 120 mg / kg. Moreover, it increased the latency time of convulsions induced by INH at the doses of 80, 100 and 120 mg / kg.