A Comparison of Nitroglycerine, Bisphosphonates and their Combination in the Management of Post Menopausal Osteoporosis

The incidence of osteoporosis is rising in post-menopausal women and so is the incidence of fractures. A large number of drugs like calcium, vitamin D, bisphosphonates, nitroglycerine etc. are available for osteoporosis. In this study we will compare the effect of Nitroglycerine, Bisphosphonates, and Nitroglycerine and Bisphosphonates (combined) on BMD. The primary outcome measure was BMD estimation at 12 months which was measured as a percentage of the baseline study at the start of study.88 patients were randomised into three groups and were followed for a period of one year. Baseline and yearly BMD was measured and expressed as a percentage of baseline BMD. It was found out that Alendronate is similar to Nitroglycerine with regards to increase in BMD (pgreater than0.05). However the percentage increase in BMD in combination group was statistically significant as compared to bisphosphonate group or nitroglycerine group (p