Formulation and In-Vitro Evaluation of Raft Forming Chewable Tablets of Ranitidine Hydrochloride

The present study was aimed to formulate and develop raft forming chewable tablets of ranitidine hydrochloride for effective treatment of Gastro Esophageal Reflux Disease. Raft forming chewable tablet was developed using pectin as a raft forming polymer. Optimization of the formulation was done using 32 full factorial design. The tablets were evaluated for various physicochemical parameters and in vitro drug release study. Tablets have shown satisfactory results when evaluated for hardness, friability, weight variation, drug content, raft strength and acid neutralizing capacity. Out of all factorial batches i. e. F1 to F9, F6 has shown promising results of raft strength as it is sufficient for the prevention of the reflux in the esophagus.