Simple and Eco-friendly Method for Synthesis of 3,4-dihydropyrimidin-2(1H) ones / thiones by Sodium Hydrogen Sulfate as Novel and Replicable Heterogeneous Catalyst

Sodium Hydrogen Sulfate supported Red Sea Sand is a novel, mild, less expensive, economic and reusable heterogeneous catalysts used for the synthesis of widely used pharmaceutically highly active moiety, 3, 4-dihydropyrimidin-2 (1H) -ones/thiones by the multicomponent Biginelli condensation of coupling between aromatic aldehydes, active methylene compounds and urea/thiourea prepared by both conventional and microwave irradiation method. The advantage of this proposed scaffold synthetic protocol is its operational simplicity, normal reaction conditions, comparatively high Yields, less reaction time required, reusable and recoverable catalytic medium with less use of solvents with the eco-friendly methodological procedure specially resulted obtained by Microwave irradiation are more convincing as compared to conventional method.