Comparison of Co-Peptin, Heart Fatty Acid Binding Protein, Troponin-I and CK-MB Assays as Diagnostic Biomarkers in Patients with Myocardial Infarction

Introduction Coronary artery disease (CAD) is the biggest non- communicable epidemic facing the world today. Myocardial infarction is a common presentation with increased mortality if the diagnosis and subsequent management is not prompt. There is an urgent need to identify a biomarker or a battery of biomarkers which can help the clinician in early diagnosis with reasonable sensitivity and specificity. This study compared the efiicacy of co-peptin, heart fatty acid binding protein, troponin I and CK-MB as diagnostic markers for myocardial infarction. Methods The present study was undertaken with 60 acute myocardial infarction patients 60 age and gender matched healthy subjects in a tertiary care hospital. Co-peptin and Heart Fatty Acid Binding Protein levels were estimated by commercially available ELISA kits provided by DRG International, Germany. Troponin I levels were quantitated on automated electro-chemiluminescence provided by Roche, Germany using commercially available kits. CK-MB was quantified on Beckmann Coulter AU400 using commercially available kit. Results The serum levels of co-peptin, heart fatty acid binding protein, troponin I and CK-MB were significantly higher in the cases as compared to controls. Maximum area under the curve is covered by Co-peptin and Troponin (pless than0.001). Conclusions Our study demonstrated that troponin I was the best marker for MI with the highest area under curve followed by co peptin and then HFABP.