A Comparative Study of Intracervical Instillation of PGE2 Gel (O.5mg) Versus Vaginal Tab PGE1 (600?g) for Second Trimester MTP

Objective A Comparative Study Of Intracervical Instillation Of PGE2 Gel (O.5mg) Versus Vaginal Tab PGE1 (600g) For Second Trimester MTP. Material and Methods The study was undertaken in the department of Obstetrics and Gynecology at New Civil Hospital, Surat from March 2015-November 2015. Sixty consenting women willing for 2nd trimester MTP coming to New Civil Hospital Surat were randomly divided in two groups. Group A (30 subjects) induction was done with intracervical instillation of 0.5mg PGE2 gel 12hrly after reassessment for maximum 3 doses. Group B (30 subjects) induction was done with tab PGE1 600g per vaginally after reassessment every 6 hrly upto maximum 4 doses. Result Mean age of subjects was 24years in Group A (PGE2) and 23.9 years in Group B (PGE1). Most of the subjects enrolled for second trimester MTP were having pregnancy between 14-16weeks. The mean drug instillation of group A was 2.1 times while in group B was 2.9 times which was statistically significant. The mean induction abortion interval in group A was 21.5hours and that of group B was 15.4 hours which was statistically significant. The success rate of group A was 93.3 % while that of group B was 96.6 % The difference in final outcome was statistically not significant. Conclusion Second trimester termination of pregnancy using PGE1 (Misoprostol) was found safe and effective with shorter induction abortion interval. Compared to other drugs available for second trimester MTP PGE1 (Misoprostol) is cost effective, can be stored at room temperature, lesser side effects and complications and with higher success rate.