Correlation between Plasma Protein Carbonyl Adducts and RBC Reduced Glutathione Level in Beta Thalassemia Major Patients in Southern Asian Region

Blood transfusion therapy is mainstay of therapy and life-saving for patients with beta thalassaemia major. It is associated with an iron overload and the resultant increase in oxidative stress. The evaluation of carbonyl group contain blood protein is useful bio-marker for oxidative stress. All serum antioxidant including glutathione is also altered due to oxidative injury. However, no studies could be found in India describe the correlation between plasma protein carbonyl adducts (PC adducts) and RBC reduced glutathione ( RBC GSH). Accordingly we carried out the present study to evaluate a correlation between plasma PC adducts and RBC GSH in proved cases of beta thalassemia major of Indian origin. In this present study, it was found that in patients of beta thalassemia major RBC GSH is inversely correlated with OS marker plasma PC adducts