A Prospective Study to Evaluate Adverse Drug Reaction Following HAART Therapy in a Tertiary Care Teaching Hospital

Background. Highly active antiretroviral therapy (HAART) is usually effective in reducing plasma HIV RNA levels and in gradually increasing CD4 cell counts. The present study was undertaken with the special focus on adverse drug reaction due to the ART drug Methodology 328 consecutive AIDS patients included for the study and they were registered for ART drug treatment All patients were informed about the adverse reactions to the ART drugs and all the adverse effects developed by patients were note Results. Stavudine combinations were preferred (80 %) more than Zidovudine combinations. Nevirapine was withdrawn due to one or other adverse reactions or due to hepatic illness in about 10 % of cases. The predominant system involved was Gastro intestinal tract 25.6 % followed by central nervous system (16.5 %), Dermatological system (3.9 %), Reticuloendothelial system (3 %) and miscellaneous manifestations (12.2 %).