A Study of Adverse Effects of Fluoroquinolones

Fluoroquinolones are the quinolone anti microbials which are known to have one or more fluorine substitutions. The first generation fluoroquinolones which was introduced in 1980s have one fluoro substitution. This was very affective in cases of gram negative bacterias. In the 1990s, compounds with additional fluoro and other substitutions have been developed further extending anti microbial activity to gram positive cocci and also anerobes which also has higher metabolic stability. This study puts in a sincere effort to understand in depth the tendinitis and rupture complications caused by the drugs which belong to fluoroquinolones. This study is intended to help the general practisioners and the practicing orthopedicians to know the depth of the disease and to attend the primary cause of the tendinitis and associated rupture secondary to the use of fluoroquinolones. Forty patients were selected who attended the Department of Internal Medicine. The present study was done in the Department of Internal Medicine at Kanachur Institute of Medical Sciences, Mangalore. The present study was done from April 2016 to September 2016. All statistical analysis was done using latest SPSS (2015) software. California. There is a positive significant relation between the tendinitis and tendon rupture complications associated with the use of Fluoroquinolones. The study successfully shows the association. In a country like ours where these Fluoroquinolone drugs are used very commonly has to check its utilization in a proper way.