Synthesis, Spectral Studies and Antimicrobial Screening of 18-Membered Macrocyclic Complexes of Mn(III) and Fe(III)

A noval series of macrocycles of the type [MLX]X2 (where M = Mn (III) and Fe (III), L=18- membered trioxa-diazamacrocycle, X = Cl-, CH3COO-) have been synthesized by (1+1) cyclocondensation of 4, 7, 10- trioxatridecane-1, 13-diamine with -diketones such as pentane-2, 4-dione, 1-phenylbutane-1, 3-dione and 1, 3-diphenylpropane-1, 3-dione in the presence of trivalent metal salts. The complexes have been characterized with the help of elemental analyses, molar conductances, magnetic measurement, electronic, H1NMR, IR and mass spectral studies. On the basis of these studies, a six coordinate distorted octahedral geometry for all these complexes has been proposed. These macrocycles were also tested for their in vitro antimicrobial activities on some pathogenic bacterial strain Streptomyces griseus (gram-positive, MTCC 706), Escherichia coli (gram-negative, MTCC 1652), Staphylococcus aureus (gram-positive, MTCC 737), Pseudomonas aeruginosa (gram-negative, MTCC 1688) and antifungal activities against Trichoderma Reesei (MTCC 164), Aspergillus niger (MTCC 282), Penicillium funicolusum (MTCC 1013) and Fusarium oxysporium (MTCC 2480).