Comparison between Oral Simvastatin and the Addition of Mung Bean Sprout (Vigna radiata) Extract to Improve Lipid Profile and Decrease F2-isoprostane Level in Wistar Male Rats (Rattus norvegicus) with Dyslipidemia

Background: One of the main factors causing atherosclerosis and oxidative stress in the body is dyslipidemia. Mung bean sprouts extract (Vigna radiata) is known to contain various components and antioxidants that play a role in improving lipid profiles and F2 isoprostane. This study examined total cholesterol, triglyceride, HDL, and LDL levels as an indicator of dyslipidemia and F2 isoprostane as an indicator of oxidative stress. Methods: Experimental randomized pretest posttest control group design was used in this study. The research?s samples were 16 male white rats aged 2-3 months, weighing 180-200 grams which were given a high cholesterol diet to achieve dyslipidemic state (total cholesterol level ?200mg/dl). Samples were divided into two groups. The control group was given simvastatin 0.36g/200g BW and 1 ml distilled water as a placebo. The treatment group was given simvastatin 0.36g/200g BW and mung bean sprouts extract 200mg/200g BW for 42 days. Lipid profile and F2 isoprostane were measured using blood serum. Results: The results showed that there was no significant difference on the mean reduction value of total cholesterol, where in the control group the result was 13.01 ? 8.61 mg / dl while in the treatment group it was 9.31 ? 6.81 (p = 0.358). There was no significant difference on the mean reduction value of triglycerides where in the control group the result was 22.5 ? 5.91 while in the treatment group it was 29.08 ? 8.32 (p = 0.092). There was no significant difference on the mean reduction value of LDL where in the control group the result was 12.01 ? 6.02 while in the treatment group it was 7.71 ? 6.04 (p = 0.176). There was no significant difference on the mean increasement value of HDL where in the control group the result was 3.51 ? 4.59 while in the treatment group it was 4.21 ? 1.50 (p = 0.687). There was a significant difference on the mean reduction value of F2 isoprostane where in the control group the result was 2.07 ? 0.45 while in the treatment group it was 4.95 ? 0.46 (p less than0.001). Conclusion: It can be concluded that the addition of mung bean sprouts extract does not improve lipid profile significantly but decreased F2 isoprostane level significantly in dyslipidemic male Wistar strain white rats (Rattus norvegicus) that received oral simvastatin.