Congenital Citomegalovirus Infection in Eleven Months Old Boy: A Case ReportJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 6)
Publication Date: 2021-06-05
Authors : A A Ratna Purnama Santhi; I Wayan Gustawan; Made Gede Dwi Lingga Utama;
Page : 777-781
Keywords : congenital CMV infection; ganciclovir; valganciclovir;
Congenital cytomegalovirus (CMV) infection is the most common cause of neurological handicapped in pediatric. This infection can be symptomatic and asymptomatic. A symptomatic infection will result in worsen prognosis for severe neurological handicapped. Case: We reported an 11-month-old baby with a history of jaundice since birth, abdominal enlargement dan small head circumference. From the physical examination, we found hepatomegaly, lien Schuffner 2, and microcephaly with head circumference below -2 SD since birth. The patient still can respond to auditory and visual stimulus. Laboratories examination reveal reactive anti-CMV IgG and non-reactive anti-CMV IgM. Further examination shows quantitative PCR beyond the normal range for CMV-DNA. Other examination showed leukocytosis, anaemia, thrombocytopenia, prolonged hemostatic function, proteinuria, hemoglobinuria, bilirubinuria, high level of procalcitonin, hypo-albumin, elevated liver function, elevated direct, indirect, and total bilirubin, high level of alkali phosphatase and gamma GT and low level of total protein and globulin. The patient was diagnosed with congenital CMV infection with liver failure, hypo-albumin and prolonged hemostatic function. The patient was planned to treat with intravenous ganciclovir. Patient was died because of acute respiratory distress of pneumonia before treatment. Conclusion: We reported a caseofcongenital CMV infectionwhichemphasize in antiviraltreatmentwithganciclovir. Excellent timing and suitable indication will result in a better prognosis for the neuro developmental outcome and long-term risk of handicapped. Patient was died before treatment.
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