Potency of Secretome in Reproductive Regenerative Medicine

Aging will arise in all biological creatures. The process is including decreased function of various organs and physical alterations. According to anti-aging medicine, the process of aging considered a disease that can be prevented, treated, and even treated returned to its optimal state like still young. Reproductive aging is marked by total plasma testosterone levels in men decrease between 1-2% per year starting around age 40. The decreasing in testosterone is multifactorial. Adult stem cells especially MSC in the niche microenvironment of stem cells are the functional units of tissue homeostasis and regeneration. MSC media has a therapeutic effect obtained from the secretion and release of the trophic molecule, which is now known as the secretome. MSCs may support or attract components of the stem cell niche and / or mimic non-existent niche cell paracrine signals. IGF is present in the MSC secretome and promotes the production of testosterone by Leydig.