Comparative Study of the Quality Control of Amoxicillin Sold in Niamey City by Thin Layer ChromatographyJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 6)
Publication Date: 2021-06-05
Authors : Salifou Karimoune Fadjimata; Amadou Tidjani Ilagouma;
Page : 1418-1420
Keywords : Amoxicillin; TLC; pharmacies; street vendors; Niamey;
The present study describes comparative analysis of Amoxicillin sold in Niamey city by Thin Layer Chromatography. This comparison aimed to investigate the quality of on eleven samples distributed as follows whichfive samples are from pharmacies, five samples are from street vendors and one sample specialty used as reference to check the quality control of them. The different reagents used are: Hydrochloric acid (HCl) 32-36%, acetone, distilled water, ethyl acetate and acetic acid. All samples migrated in proposed diluent. This shows that all samples contain the active ingredient substance of amoxicillin. The percentage of the active ingredient were calculated as per protocol of Clarke?s analysis of drugs and poisons in chemistry guidelines. Itvaries from 97,27 to 110,54 and 94,73 to 100 respectively for pharmacies and street vendors. According to the results of the different frontal reports, each sample contains the percentage of active principle recommended by WHO which is 80 to 100 %. This technique can be used for practical work or tutorial and laboratories where drug quality control mechanism is not often checked.
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