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Journal: Journal of the Grodno State Medical University (Vol.19, No. 3)

Publication Date:

Authors : ;

Page : 306-310

Keywords : perinatal factors; gene polymorphism; folate; autism spectrum disorders;

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Topicality. In child psychiatry, there is an urgent task to identify significant factors that contribute to the development of autism spectrum disorders (ASD). Aim. To identify combinations of genetic and perinatal risk factors of autism spectrum disorders in children. Material and methods. We examined 102 children with ASD and 85 healthy children aged 2 to 10 years. The analysis of perinatal risk factors for the development of ASD was carried out. To determine the polymorphic variants of the folate cycle genes, genomic DNA isolated from whole blood was used. The determination of gene polymorphisms was performed by real-time PCR. Results. By constructing a mathematical model and ROC analysis, significant combinations of genetic and perinatal factors associated with the risk of ASD were identified: MTRR A66G (AG; G/G), MTHFR C677T (T/T), threat of interruption and «hypoxia». Conclusions. The obtained mathematical model is adequate and reflects significant combinations of risk factors for ASD.

Last modified: 2021-07-15 22:29:07